Prime Video has released a brief trailer for The Boys season 5 episode 5, and it throws Jared Padalecki, Jensen Ackles and Misha Collins back into the same violent frame for the first time in years. Padalecki tells Homelander he’s "come to the right place," Soldier Boy looms right behind him, and the clip ends with blood, guts and a promise that the reunion will not be gentle.
The trailer gives fans of the three actors something they have waited a long time to see again. Padalecki, Ackles and Collins spent 20 years and 15 seasons starring as Sam, Dean and Castiel on Supernatural, the fantasy-drama created by The Boys creator Eric Kripke. Kripke has confirmed that the trio will appear in the same frame, and the preview backs that up with a shot of Soldier Boy grabbing Collins by the throat, Padalecki suddenly covered in blood and guts, and Stan Edgar coolly saying it "should be a delightful reunion." Soldier Boy then looks at the bloodied Padalecki and shrugs, "Good times," a line that lands as both joke and threat.
That connection matters because The Boys has increasingly leaned into casting and story overlaps as it heads toward its final stretch. The show is releasing season 5 weekly on Prime Video, and the new trailer suggests episode 5 will be one of the season’s most overt fan-service moments. It also keeps the focus on where the series is heading around its core power players, including Laz Alonso’s darker turn as Mother’s Milk and the broader franchise shift that follows the end of Gen V’s second-season run.
What the trailer does not do is spell out exactly how Padalecki and Collins fit into the story. The source material here says only that they will appear in the same frame, not which characters they are playing, and the clip keeps the reveal just out of reach. That restraint is part of the tease: the reunion is real, but the show is still holding back the reason it has brought three Supernatural leads into this blood-soaked corner of The Boys.
For viewers, the answer to the question the trailer raises is already clear. This is not a throwaway cameo or a coy nod to an old series. It is a deliberate on-screen reunion built into the last season’s weekly rollout, and the show is using it to turn a familiar cast memory into fresh damage.
